I link to Boscoh.com, a structural bioinformatician/blogger. He explains of his opinion on the greatest paper in the protein folding field of 2011:
Protein 3D Structure Computed from Evolutionary Sequence Variation
there, that’s in a big enough font. I can’t say I understand this in the slightest, but I believe the basic gist is that Marks et al. have shown from a multiple sequence alignment they can calculate a low resolution protein structure with good confidence. This opens doors to allow structure prediction with low computing costs.
I hope to learn more about the significance of these findings in the future